I’m not going to bother with a lengthy introduction (I’m lazy)… Instead, gaze upon my random thoughts on soloing stuff at level 100!
Talents
Second Wind: Don’t bother. It’s useless for MoP soloing, and has VERY limited utility in earlier raids. Sad, really, as this used to be the MANDATORY talent for soloing.
Enraged Regeneration: This is my personal choice for soloing. It’s a big self-heal, has a fairly short and reliable cooldown, and has great synergy with Last Stand/Rallying Cry (if you have access to them).
Impending Victory: Meh. Not as bad as Second Wind, and not as reliable as ER. Take it if you think you’ll be fighting a LOT of adds, and you might get some decent mileage out of it.
The remaining talent choices are largely a matter of preference. This isn’t progression raiding, so there aren’t any must-haves. Pick what makes you feel most comfortable.
Specs
Tanking: Protection (obviously). Mandatory for pushing the envelope (Mogu’shan Vaults and beyond), and a safe bet if you’re averse to wiping on easier content.
DPS: Arms/Fury/Gladiator. A personal choice, really. Use what you like (or have the best gear for). I LOVE Gladiator Stance, and it lets me get double-use out of my raid tanking gear, so that’s what I’m currently using. YMMV.
Raids
▼ Ulduar
It’s a 25-man faceroll! In fact, if you’re careful, you can save a few precious minutes and do the Flame Leviathan fight sans vehicle. Just pick up a chopper, race through the gauntlet, dismount and AoE the trash that comes running in, then NUKE the boss on foot. FL hits hard, but with careful use of CDs it’s not that bad.
▼ Icecrown Citadel
The entire raid is easily soloable at 25 Heroic difficulty (minus Dreamwalker, but she’s skippable). It’s an easy 30-40 minute farm for the Invincible mount, if you’re so inclined.
▼ Cataclysm Raids (Tier 11)
Blackwing Descent: Easy on 25 Heroic difficulty. In fact, due to the nature of lava damage and the Heroic platform mechanic, Nefarian is easier on Heroic than he is on Normal!
Bastion of Twilight: *Mostly* easy on 25 Heroic, EXCEPT for Valiona and Theralion. Their Blackout attack doesn’t seem to have been “squished”, so it’ll one-shot you on 25H. It is survivable on 25 Normal with all defensive CDs popped, so be prepared and kill them before you get a second Blackout.
Throne of the Four Winds: This place is as annoying as ever. If you’re mount farming, set it to 10 Normal and just faceroll it, since it’s not really worth the headache to attempt the fights on a harder difficulty.
▼ Firelands
Fairly easy to solo on 25 Heroic difficulty, with a few exceptions.
Beth’tilac: Cinderweb Spinners have a nasty perma-stun on Heroic, so you’ll need to get topside and kill Beth as quickly as possible. When she drops down, follow her and finish the job before you get stunned into oblivion.
Baleroc: is pretty tough on 25H. If you’re tanking, the Decimation Blade is lethal; if DPSing, the Shards will kill you if the Blade doesn’t. It’s a DPS race, pure and simple.
Shannox: A royal PAIN if you’re DPSing, due to the antics of Rageface. I suggest playing it safe and going Prot, if possible.
▼ Dragon Soul
The entire raid is a cake walk on 10 Normal/Heroic. The first three bosses are pretty easy all the way up to 25 Heroic, but it gets pretty rough after that. If you’re farming mounts, I’d keep it on 10N unless you need it on Heroic for the (admittedly pretty sweet) tier transmog gear.